Rarely. Entamoeba histolytica lives in the skin and causes a problem called cutaneous amoebiasis or amoebiasis cutis. The amoeba produces a swelling in the skin which may turn into a painful ulcer. Tissue in the area dies, and pus may be released from the ulcer.
The amoeba reaches the skin directly or indirectly. A direct infection involves contamination of the skin by the material containing the amoeba, such as feces. Indirect infection involves the transfer of the amoeba through the infected person’s body to their skin.
Acanthamoeba and Balamuthia mandrillaris are other amoebas that can infect the skin. Fortunately, both infections are rare and most often occur in people with a compromised immune system, but they can be unpleasant for people who have them.