Chloroform in the Environment and Its Potential Health Dangers
An Environmental and Health Problem
Chloroform is an interesting chemical. It's famous for its ability to act as an anesthetic and is useful in industry and science laboratories. It's a toxic substance, however, and can cause serious health problems when it's sufficiently concentrated. These problems include organ damage and heartbeat irregularities. At high concentrations, inhalation of chloroform can depress the respiratory system so much that death occurs. The chemical is also strongly suspected of increasing the risk of cancer.
Chloroform is widespread in the environment and is made both naturally and artificially. Most people are exposed to low levels of the chemical, but some people—especially those working in certain industries—are exposed to higher levels. Fortunately, there are ways in which we can limit our exposure to chloroform.
Properties of the Chemical
Chloroform is also called trichloromethane and has the formula CHCl3. At room temperature, it's a clear, colorless, and dense liquid that has a pleasant odor and is nonflammable. It tastes sweet but produces a hot, burning sensation in the mouth and throat. Contact with the liquid produces sores on the skin. The liquid form of chloroform is a volatile substance. This means that it has the tendency to change into a vapor at normal environmental temperatures.
Chloroform is made synthetically for industrial use and is produced naturally from chlorine in the environment. It's also made by some seaweeds and microalgae. Its non-medical applications are useful, but the chemical needs to treated with care when it's used in laboratories and industrial processes.
Odor thresholds vary greatly. Do not rely on odor alone to determine potentially hazardous exposures.— New Jersey Department of Health (with respect to chloroform detection)
Discovery of Chloroform and Its Ability to Act as an Anesthetic
Chloroform was discovered in 1831 and 1832 by three different scientists working independently—an American doctor named Samuel Guthrie, a French chemist named Eugene Soubeiran, and a German chemist called Justus von Liebig.
A few years after its discovery, scientists realized that chloroform could act as an anesthetic. It causes a person to lose consciousness because it depresses central nervous system activity. The central nervous system consists of the brain and the spinal cord.
James Young Simpson, a Scottish obstetrician and surgeon, popularized the use of chloroform as an anesthetic. He discovered the chemical's abilities from personal experience. In 1847, Simpson and some friends deliberately inhaled chloroform to explore its effects. They were all rendered unconscious, but luckily they didn't inhale enough vapor to kill themselves. The experiment was potentially dangerous. Simpson was very impressed by the results of his investigation.
Chloroform quickly replaced ether as the anesthetic of choice, since unlike ether it didn’t have a strong and unpleasant smell, could be used in smaller quantities, started to work more quickly, and wasn’t flammable.
In chemistry, the word "ether" refers to a family of chemicals. Diethyl ether is the chemical name of the compound that was once used as an anesthetic.
Chloroform in Queen Victoria’s Life
Chloroform gained prominence when it was administered to Queen Victoria in 1853 during the birth of Prince Leopold, her eighth child. She also inhaled the chemical in 1857 during the birth of Princess Beatrice, her ninth and final child. The administrator of the drug was Dr. John Snow. He used enough chloroform to relax his patients during childbirth but not enough to render them unconscious. This required a very careful calculation of dose.
Chloroform was found to be very effective as an anesthetic. However, one serious problem with its use in medicine is that it has a low margin of safety. This means that there is only a small difference between a dose that is helpful and a dose that is harmful. In addition, chloroform inhalation for the purpose of anesthesia produces a number of potentially dangerous side effects.
Potential Health Dangers of Chloroform
Today scientists know that chloroform is not the wonder chemical that it first appeared to be. When it's inhaled, it can cause heartbeat irregularities that may be deadly. It can also cause liver and kidney damage. High concentrations of the chemical may produce headaches, dizziness, and gastrointestinal problems such as nausea and vomiting. In addition, chloroform has been classified as a probable carcinogen—a chemical that can cause cancer. Newer anesthetics have replaced chloroform in the operating room.
Chloroform is rapidly absorbed through both the respiratory tract and the gastrointestinal tract. It can also be absorbed through the skin. Once inside the body, it travels widely. Most of the chemical is eventually broken down or leaves the body by exhalation and excretion, but some may collect in body fat and organs.
Chloroform can be dangerous without being absorbed. Ultraviolet radiation from sunlight causes chloroform and oxygen in the environment to slowly react, forming a gas called phosgene. This gas is more toxic than chloroform and is especially dangerous if it collects in an enclosed space and becomes concentrated. Phosgene was used as a chemical weapon in World War One. Its formula is COCl2 or CCl2O. Both formulas are considered to be correct.
Interestingly, phosgene is an important industrial chemical today. The CDC (Centers for Disease Control and Prevention) says that it's used to make plastics and pesticides. Anyone who has to deal with the chemical needs to take adequate precautions and be very careful. Phosgene is a strong irritant in both its gaseous and its liquid form. It damages tissues in the nose, throat, and lungs and causes choking. It also irritates the skin and eyes.
Even chemists working with chloroform need to be careful with the chemical. The video below discusses safety tips for dealing with chloroform and other substances in the laboratory.
Chlorinated Water Benefits and Disadvantages
Research has shown that the biggest contributor to chloroform in our bodies is chlorinated water. Chlorine is often added to drinking water and swimming pool water to kill bacteria and other microbes. This job is very important, but unfortunately using chlorine as a disinfectant can cause problems.
Chloroform and other disinfection by-products form when chlorine reacts with organic molecules in water. In swimming pools, these organic molecules can come from shed skin cells, sweat, urine, cosmetics, sunscreens, leaves, and soil, for example. Once they are formed, chloroform and the other disinfection by-products are absorbed though the skin or enter the body when a person swallows water or breathes vapor coming from the water.
Chloroform Production in Homes and Industry
Scientists have found that chlorinated water in homes produces vapor containing chloroform, especially if the water is hot. The hotter the water, the higher the concentration of the chemical in the air. Hot shower or bathwater, hot cooking water, and hot laundry or dish washing water can all increase the concentration of chloroform in a home. Chlorine used to clean toilets or to bleach clothes can have the same effect.
Certain industries release chloroform into the atmosphere. They use the chemical as a reactant in chemical reactions and as a solvent—a chemical that dissolves other substances. Chloroform is used in some countries to produce a refrigerant known as R-22. The use of R-22 is gradually decreasing, however, since it causes ozone depletion in the atmosphere. Chloroform is also released into the air from pulp and paper mills and from landfills and hazardous waste sites.
Chloroform enters our bodies when we drink chlorinated water and eat food containing the chemical. The chemical is present in some foods because chlorinated tap water was used to produce them.
In the past, chloroform was added to some cough medicines. In 1976, the United States banned this use of the chemical. Cough syrups in some countries still contain it, however.
How to Reduce Chloroform Exposure
The effects of chloroform on our bodies depend on the concentration of the chemical and the length of time that we are exposed to it. There are several steps that we can take to reduce the absorption of the chemical. The last step in the list below may require the help of officials.
- Use water and shower filters that reduce the chlorine level in home water.
- Take shorter showers and baths.
- Use less hot water in the home.
- Open windows to improve ventilation in areas where chloroform is likely to form.
- Avoid the use of cleaning products that contain chlorine.
- If you could be exposed to chloroform while you're doing a job at home or at work, make sure that you follow all of the recommended safety precautions.
- Use other swimming pool disinfection methods instead of chlorine. This step is especially important for someone who is a frequent swimmer in a pool.
Maintaining a Safe Environment
Most of us don't need to worry excessively about the amount of chloroform that we absorb. It is a good idea to be aware of the potential dangers, however, and to reduce the intake of the chemical whenever possible. People working in jobs where chloroform is made or used or those living near a facility that releases it into the environment need to be careful. The risk of ill effects is highest for these people.
- Chloroform facts and public health information from the Agency for Toxic Substances and Disease Registry (a government organization)
- Information about chloroform from the New Jersey Department of Health
- Chloroform formation and hazards from the EPA (Environmental Protection Agency)
- Facts about Sir James Young Simpson from the Gazetteer for Scotland
- Phosgene facts from the Centers for Disease Control and Prevention
- Information about phosgene from PubChem, National Library of Medicine
This content is accurate and true to the best of the author’s knowledge and does not substitute for diagnosis, prognosis, treatment, prescription, and/or dietary advice from a licensed health professional. Drugs, supplements, and natural remedies may have dangerous side effects. If pregnant or nursing, consult with a qualified provider on an individual basis. Seek immediate help if you are experiencing a medical emergency.
Questions & Answers
How does the chemical Chloroform affect the environment?
Researchers say that at its usual environmental concentration chloroform is unlikely to harm the environment significantly. These facts may not be true if the level of chloroform is increased due to some type of accident or another event, however. There are concerns that a high concentration of the molecule might harm some aquatic organisms. Also, it might react with other types of air pollution to form ground-level ozone, which can damage crops, though researchers seem to disagree about this possibility.Helpful 2
How does well water that has been tested with a high level of chloroform affect the body?
The potential effects of chloroform in water depend on its concentration. Since you’ve discovered that the water in your well contains a high level of the chemical, you should contact your local public health department or some other department in your local management or government organization. They will likely ask about the specific concentration of the chemical discovered in the test and then give you recommendations about what to do next. It’s important that you do this so that you know whether it’s safe to use the water.Helpful 3
© 2010 Linda Crampton