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Pigments in the Human Body: Functions and Health Problems

Linda Crampton is an experienced teacher with a first-class honors degree in biology. She writes about the scientific basis of disease.

Brown eyes contain a lot of the pigment known as eumelanin.

Brown eyes contain a lot of the pigment known as eumelanin.

Functions of Pigments in the Body

A pigment is a chemical that has a specific color. Biological pigments color our body and its products, but this isn't their primary function. The chemicals often play vital roles in the daily operation of the body. For example, melanin is a yellow to black pigment in our skin that helps to protect it from sun damage. Rhodopsin is a purple chemical in our eyes that enables us to see in dim light. Hemoglobin is a red pigment in blood that carries oxygen from our lungs to our cells.

Some pigments in our bodies are waste products and appear to have no function. Others are very important to our well-being and even to our survival. In some cases, health problems can develop if too much pigment collects in the body or if too little is made.

A melanocyte is a star-shaped cell that makes melanin.

A melanocyte is a star-shaped cell that makes melanin.

Melanin in the Skin

Melanin is the main pigment in skin, where it’s made by cells called melanocytes. Two forms of skin melanin exist—eumelanin, which is brown or brown-black, and pheomelanin, whose color ranges from yellow to red. The molecules of melanin are present in various proportions in the skin of different people to produce the range of human skin colors. Blood vessels in the skin also contribute to skin color due to the presence of hemoglobin, a red pigment in blood.

Melanin is deposited near the surface of the skin. It absorbs dangerous ultraviolet rays from the sun, preventing the UV light from traveling deeper into the skin. Ultraviolet light can cause DNA damage in cells as well as skin cancer, so melanin is an extremely important molecule. As noted below, however, it doesn't absorb all of the dangerous radiation that strikes our body. We all need to take precautions to prevent skin damage from sunlight, whatever the color of our skin.

Sunscreen or protective clothing is necessary for everyone, even for people with lots of melanin in their skin.

Sunscreen or protective clothing is necessary for everyone, even for people with lots of melanin in their skin.

Everyone has the same number of melanocytes, but some people make more melanin than others. If those cells make just a little bit of melanin, your hair, skin and the iris of your eyes can be very light. If your cells make more, then your hair, skin, and eyes will be darker.

— WebMD

Melanin Concentration

When light-colored skin is exposed to intense sunlight, it responds by making more melanin than usual. The extra melanin provides additional (but not complete) protection from UV damage and gives the skin a tanned appearance. Although a tan is often considered to be desirable, it's an indication that the skin has been under stress from sunlight exposure.

Since dark-colored skin already contains a lot of melanin before being exposed to sunlight, it provides more protection from sun damage than light-colored skin. However, this protection still isn't complete. Dermatologists say that people of all skin colors should wear sunscreen.

Melanin in the Hair and the Iris of the Eye

Hair Color

Melanin is found in other areas of the body besides the skin. Both eumelanin and pheomelanin contribute to the color of hair. The eumelanin exists in two varieties—brown eumelanin and black eumelanin. Pheomelanin colors the hair yellow or orange. The proportions of these pigments determine hair color.

Structure of the Iris

Melanin also plays a role in determining the color of the eye. The iris is the coloured part of the eye. The outer and thicker layer of the iris is called the stroma. Behind this is a thin layer called the iris pigment epithelium. The pigment epithelium contains melanin. The stroma may or may not contain the chemical.

The stroma of the iris plays an important role in determining our eye color. It contains collagen fibers, melanocytes in some cases, and other cells in a loose arrangement. Blue-eyed people have no melanocytes in their stroma.

Eye Color

Iris color is determined by a combination of factors related to the stroma, including the density and arrangement of the collagen fibers and stroma cells, the number of melanocytes and the amount of eumelanin in them, and the ability of the stroma to scatter light with a long wavelength, which appears blue in color to us.

People with brown eyes generally have the highest concentration of melanin in their stroma. People with green eyes have an intermediate amount. The smaller amount of melanin combined with the ability of the stroma to scatter light produces a green color. The scattering of light plays a major role in creating the color of blue-eyed people.

Melanin is also present in the inner ear, where its function is unknown. A dark form of melanin called neuromelanin is found in parts of the brain.

Carrots are rich in a pigment called beta-carotene. Our bodies convert this pigment to vitamin A. The vitamin is essential for producing a visual pigment named rhodopsin.

Carrots are rich in a pigment called beta-carotene. Our bodies convert this pigment to vitamin A. The vitamin is essential for producing a visual pigment named rhodopsin.

Rhodopsin in the Rods of the Retina

Activity of Rhodopsin

Several pigments are present in the eye and are essential to its function. Rhodopsin is located in the rod cells of the retina. The retina is the light-sensitive layer at the back of the eyeball. Rhodopsin is also known as visual purple due to its color. It functions in dim light and enables us to see shades of grey. In bright light, rhodopsin is bleached and breaks up into retinal and a protein called opsin. In the dark, the process is reversed and rhodopsin is regenerated.

Importance of Beta-Carotene

Since retinal is made from vitamin A, this vitamin is an essential nutrient for night vision. Beta-carotene is a yellow or orange plant pigment, which our bodies can convert into vitamin A. The chemical is especially abundant in carrots, so the old myth that carrots are good for night vision is actually true. Pumpkin purée and orange sweet potatoes (yams) are also great sources of beta-carotene. Green leafy vegetables often are as well. Here the orange pigment is hidden by the chlorophyll in the leaves.

Beta-Carotene Precautions

It’s not safe to eat large amounts of pre-formed vitamin A, which is toxic at high levels, but eating a large but not excessive amount of beta-carotene doesn’t seem to be dangerous. It's important to keep in mind that eating an excessive amount of even a normally beneficial nutrient could be harmful.

Research suggests that while smokers can eat foods containing beta-carotene, they shouldn’t ingest supplements, which may increase the risk of lung cancer. The same is true for people who have had a long-term exposure to asbestos fibers.


Eating large amounts of beta-carotene in food or supplements can result in some of the pigment being deposited in the skin, giving it a yellow color. This condition is called carotenemia and is thought to be harmless, at least in the short term. It is an indication that the pigment level in the diet should be reduced. however.

The cause of yellow skin should be investigated by a doctor, especially if it remains after dietary changes. The color change may be due to a health problem instead of diet, even if the affected person does eat a lot of beta-carotene.

Pumpkins are another great source of beta-carotene.

Pumpkins are another great source of beta-carotene.

Cone Pigments in the Retina of the Eye

The cone cells in the retina respond to bright light and enable us to see color and detail. Humans have three types of cone cells, which are known as the S, M, and L cones. Each type responds best to a specific range of light wavelengths, although there is some overlap in cone sensitivity.

  • S cones are most sensitive to the shorter wavelengths of light, which produce a blue color, and are sometimes called blue cones. This alternate name is a bit confusing because S cones respond to blue light but are not blue in color.
  • M cones, or green cones, are more sensitive to medium wavelengths, which produce green light.
  • The L cones, or red cones, respond best to long wavelengths, which produce red light.

The cone pigment molecules are called iodopsins and are chemically similar to rhodopsin. Vitamin A is required for the manufacture of the iodopsins, so this vitamin is important for color vision as well as for night vision. Each of the three types of cones contains its own version of iodopsin.

Zeaxanthin and Lutein in the Eye

The central part of the retina provides very detailed vision and is known as the macula. When we look directly at something, the reflected light rays from the object strike the macula. The central portion of the macula has the best vision in the retina and is called the fovea centralis (or sometimes just the fovea). The fovea contains cones but no rods. This is why when we're outdoors at night, it's useful to look at objects from the side of our visual field rather than looking directly at the objects. This allows reflected light rays from the objects to fall on the outer portion of the retina, which has rods.

Zeaxanthin and lutein are yellow pigments in the macula. These two pigments belong to the carotenoid family, just as beta-carotene does, and give the macula a yellow appearance. They are thought to help maintain the health of the macula by protecting it from light damage and possibly by reducing oxidative stress. It's known that when people ingest zeaxanthin and lutein, the levels of these pigments in the macula increases. Eggs are a good source of zeaxanthin and lutein, and so are corn and green leafy vegetables.

Egg yolk is a great source of lutein, which may boost eye health.

Egg yolk is a great source of lutein, which may boost eye health.

Age-related macular degeneration is the leading cause of vision loss in older people. As their macula degenerates, it becomes harder for a person to see a clear image. In people with AMD, the macula has a lower level of zeaxanthin and lutein than in people without AMD. Scientists suspect—but don't know for certain—that ingesting more zeaxanthin and lutein will decrease the chance of AMD development and may help to prevent the disorder from getting worse once it has started.


Hemoglobin is a red protein and pigment inside red blood cells that transports oxygen around the body. The hemoglobin is responsible for the blood’s color. One hemoglobin molecule joins to four oxygen molecules.

A normal red blood cell contains 250 million to 300 million hemoglobin molecules. Since there are 4 million to 6 million red blood cells per microliter of blood in a healthy person (one microliter = one millionth of a liter), a lot of oxygen travels through the blood. This oxygen is an essential nutrient for the estimated 50 to 100 trillion cells in the human body. These cells need oxygen to produce energy from digested food.

Red blood cells get their color from a pigment called hemoglobin. (The white cell at the bottom of this illustration is a type of white blood cell.)

Red blood cells get their color from a pigment called hemoglobin. (The white cell at the bottom of this illustration is a type of white blood cell.)

Bile Pigments

Red blood cells live for about 120 days and are then broken down by the liver and spleen. Their hemoglobin is changed into a green pigment called biliverdin. Biliverdin is then changed into yet another pigment known as bilirubin, which is yellow. Bilirubin enters a liquid called bile, which is made in the liver.

The liver sends bile to the gall bladder. The gall bladder stores the bile and releases it into the small intestine (or small bowel) when fat is present in the intestine. Bile contains salts whose function is to emulsify ingested fats. This emulsification prepares the fats for digestion by enzymes.

Bile and food that is not digested pass from the small intestine into the large intestine. Here bacteria and chemical reactions change the bilirubin into a brown pigment called stercobilin. Stercobilin leaves the body in the feces. The pigment gives feces its color.

Some bilirubin is converted into urobilin, a yellow pigment that is absorbed through the intestinal lining into the bloodstream. The kidneys excrete the urobilin in urine, giving the liquid its typical yellow color.

Bile is made in the liver and stored in the gall bladder. The hepatic ducts transport bile from the liver. The liver is a large organ that covers the gall bladder.

Bile is made in the liver and stored in the gall bladder. The hepatic ducts transport bile from the liver. The liver is a large organ that covers the gall bladder.

Pigment Disorders

Multiple disorders are caused by an insufficient or excessive amount of a pigment. Three of these disorders are vitiligo, jaundice, and iron-deficiency anemia. In vitiligo, melanin is lost from the skin. In jaundice, bilirubin collects in the skin. In iron-deficiency anemia, the blood lacks hemoglobin or the red blood cells that contain the hemoglobin.

Melanin Loss and Vitiligo

Vitiligo is a condition in which melanocytes in the skin are destroyed, resulting in white patches that contain no melanin. The cause of vitiligo is unknown, but it may develop due to the inheritance of specific genes that make a person susceptible to melanin loss. The most popular theory at the moment is that vitiligo is an autoimmune disease, however. In an autoimmune disease, the immune system mistakenly attacks the body's own cells—in this case, the melanocytes.

Someone with vitiligo needs to remember that skin patches without pigment are very susceptible to damage from sunlight. Pigmented patches can be damaged too, which is why sunscreen is important for everyone (including people without vitiligo), but areas without pigment are especially likely to be harmed by the sun.

Bilirubin and Jaundice


Hyperbilirubinemia is a condition in which bilirubin becomes too concentrated in the body. As a result, bilirubin collects in the skin and usually in the sclera (the white part of the eye) as well. The yellow color in the skin and eyes is known as jaundice.

Hyperbilirubinemia may develop if too many red blood cells are destroyed. This results in the breakdown of an excessive amount of hemoglobin and the production of too much bilirubin. The disorder may also develop due to liver damage that prevents release of bilirubin into the small intestine or due to an obstruction in the passageways that transport bile.

Newborn Jaundice

Neonatal or infant jaundice is a condition that may appear in newborn babies. The eyes and skin turn yellow because the liver is not mature enough to remove the bilirubin from the blood. A baby with the condition should be monitored carefully. A doctor may decide that no treatment is necessary. On the other hand, the disorder sometimes requires medical treatment. If it's not treated when necessary, the baby may experience brain damage. The condition is known as kernicterus. It's said to be rare, but it's something that a parent should be aware of.

Carotenemia and jaundice both involve yellowing of the skin. In carotenemia, the sclera of the eye generally remains white. In jaundice, the sclera generally develops a yellow color. A self-diagnosis shouldn't be made, however. Symptoms may vary in different individuals.

Hemoglobin and Iron-Deficiency Anemia

Red blood cell and hemoglobin destruction, an insufficient amount of hemoglobin in the red blood cells, or the production of abnormal hemoglobin can cause a number of disorders, including several types of anemia. The anemia may be mild or severe.

The most common type of anemia is called iron-deficiency anemia. Hemoglobin contains iron and can't be made without this element. If the body lacks hemoglobin, an insufficient number of red blood cells will be produced and an inadequate amount of oxygen will be delivered to the body’s tissues. Iron-deficiency anemia can arise due to a diet that is low in iron, inadequate absorption of iron, or blood loss.

The main symptom of iron-deficiency anemia is fatigue, but other symptoms may be present as well. These include the craving to eat non-food substances, such as soil or ice. This condition is known as pica.

The Importance of Pigments in the Body

Melanin, zeaxanthin, lutein, hemoglobin, and the other pigments in our body are important molecules. Investigating their functions, mechanisms of action, and interactions with other body components is very worthwhile. Some of the discoveries may lead to better treatments for specific health problems. They may also give us a better understanding of how the body works. This is a vital topic. It's also a very interesting one.


This content is accurate and true to the best of the author’s knowledge and does not substitute for diagnosis, prognosis, treatment, prescription, and/or dietary advice from a licensed health professional. Drugs, supplements, and natural remedies may have dangerous side effects. If pregnant or nursing, consult with a qualified provider on an individual basis. Seek immediate help if you are experiencing a medical emergency.

Questions & Answers

Question: Why does my daughter have brown eyes while the whites of her eyes are blue?

Answer: There are quite a lot of reasons why the sclera (the white part of the eye) turns blue. Sometimes it’s due to a thinner than normal sclera. Certain medications and diseases can cause the sclera to thin or to develop a blue color. This is why it’s important to visit a doctor to discover the reason for the color. It shouldn’t simply be accepted as normal or unimportant.

Question: What is iodopsin?

Answer: The rods in our retina contain only a single visual pigment—rhodopsin. In contrast, cones include various pigments which respond to different wavelengths of light. The terms cone opsins, photopsins, or iodopsin are sometimes used as the general name for the cone pigments. The word iodopsin has a variable meaning, however. Different sources use it to mean different things concerning cone pigments.

© 2011 Linda Crampton


Linda Crampton (author) from British Columbia, Canada on August 12, 2016:

Hi, Jean. I suggest that you watch the marks to see if they fade or disappear. I can't say what they are because I'm not a doctor. If the marks don't disappear or if you have any other concerns about them, you might want to visit a physician.

Jean C on August 12, 2016:

I do not sat in the sun never did but to-day had a lower top at the back and in the middle of my back got three big marks never had before come up just like that I am trying to find why.

Linda Crampton (author) from British Columbia, Canada on May 02, 2016:

Thank you very much, Qurat ul Ain Majeed Khan. I'm glad the article helped you.

Qurat ul Ain Majeed Khan on May 02, 2016:

Thank you so much! This hub helped me alot..

Thanks once again..!


Linda Crampton (author) from British Columbia, Canada on August 31, 2014:

I'm glad the hub was helpful for you, Ishrael.

Ishrael on August 31, 2014:

O thank God you provide the right information I need :)

Linda Crampton (author) from British Columbia, Canada on March 08, 2013:

Thank you very much for the comment, B K Karan!

B K Karan on March 08, 2013:

its great!!!! I had not known that it was the mixed proportions of different types of melanin that contributed to varying skin color. its realy great

Linda Crampton (author) from British Columbia, Canada on December 28, 2012:

Thank you for the comment and the information, Dr. Ibrahim (although in the article I didn't refer to the intake of carotenoids once macular degeneration has already begun). The scientific evidence for the benefits of lutein and zeaxanthin is growing. They seem to be very useful nutrients!

Dr.Ibrahim on December 28, 2012:

Nice information about some pigments and food related to their metabolism. It is not true to say foods containing caretonoids are of no use once macular degeneration is developing. In fact the progress of the degeneration will certainlty be retarded though not stoped completely. More over there are a lot of benefits in eating vegetables like fibre, minerals and vitamins besides their nutrient values.


Linda Crampton (author) from British Columbia, Canada on November 25, 2012:

Thanks for the comment, Maurice!

Maurice on November 25, 2012:

Worth reading. Thanks for the research efforts!

Linda Crampton (author) from British Columbia, Canada on August 09, 2012:

Thank you for the visit and the comment, sarmin898.

Sarmin Sultana from Bangladesh on August 09, 2012:

Great article.very helpful

Linda Crampton (author) from British Columbia, Canada on May 21, 2011:

Thank you very much, souleru!

souleru on May 21, 2011:

Wish I learned high school bio from you ;)

Linda Crampton (author) from British Columbia, Canada on April 22, 2011:

Hi, prasetio. Thanks for the visit and thanks for the rating too! Yes, pigments have very important functions in humans. It's interesting to learn about them.

prasetio30 from malang-indonesia on April 22, 2011:

We need this pigment. Everybody has different pigment. Thanks for writing this. You have valuable information here. Rated up! Take care..


Linda Crampton (author) from British Columbia, Canada on April 20, 2011:

Thank you very much for your kind comment, kashmir56. This was an interesting hub to create!

Thomas Silvia from Massachusetts on April 20, 2011:

Hi AliciaC, thank you for this very interesting hub, not only was it a fascinating read i learned a few things has well .

Awesome hub !!!

Linda Crampton (author) from British Columbia, Canada on April 20, 2011:

Thank you very much for your comment, Chatkath.

Thanks for the visit and comment, Tony.

Tony McGregor from South Africa on April 20, 2011:

Great information and very useful. I think some of my fellow melanin-challenged (i.e. so-called "white") writers here on HubPages could learn from reading this.

Love and peace


Kathy from California on April 19, 2011:

Very interesting stuff Alicia! Easy to understand and well written, thanks for sharing!!!!

Linda Crampton (author) from British Columbia, Canada on April 19, 2011:

Hi, Tina. It is a shame that so many young people try to get a tan, injuring their skin at the same time. Green leafy vegetables are so good for our health that I think we should always eat a lot of them, even if they can't repair damage that has already been done! Thank you for your comment and rating.

Hi, Simone. Thank you for your comments. I appreciate them very much! Thanks for the vote too.

Simone Haruko Smith from San Francisco on April 19, 2011:

This is so interesting, AliciaC! I had not known that it was the mixed proportions of different types of melanin that contributed to varying skin color. Voted up!

Christina Lornemark from Sweden on April 19, 2011:

A very informative and interesting article about pigments in the human body. We do need to be more observing about our skin in the sometimes fanatic chase for a beautiful tan. As soon as the sun begins to shine in spring the young girls starts to work on a quick tan! They have so many years ahead of them and run the risk of so many sunburns.

I guess it is no use to ingest more green leafy vegetables and such once the sight already has decreased?

Up/useful! Tina