How Does Caffeine Work?
Caffeine is the most widely consumed drug in the world. From coffee to tea, we all love to get our daily hit of the stuff on sleepy mornings. But what is caffeine, exactly? Where does it come from, how does it work, and are there side effects from drinking too much of it?
What is Caffeine?
Caffeine is a nitrogenous molecule with a chemical formula of C8H10N4O2. In its pure form, it’s a white powder that looks a little like cocaine. Like cocaine, it’s classed as a stimulant drug because of the 'kick' it gives the body. Unlike cocaine, it’s perfectly legal and is drunk by the gallon by sleep-deprived students and workers across the globe. Caffeine’s chemical name is 1,3,7-trimethylxanthine, which is pretty cool but also pretty impossible to pronounce correctly.
Where Does Caffeine Come From?
Caffeine comes from a variety of natural sources, including tea leaves, kola nuts, cacao beans, guarana and, of course, coffee beans. It’s used in a wide range of commonly consumed drinks, including coffee, hot chocolate, tea, coca-cola, energy drinks and even in some types of chewing gum.
Caffeine content (mg/100ml)
Coffee: Flat White
How Does Caffeine Work?
To understand how caffeine really works a little background knowledge is needed. The human body has several mechanisms that regulate how tired you feel. One of these mechanisms works through the secretion and detection of adenosine, a neurochemical that is released as a kind of by-product of your neurons firing. As the day wears on and your neurons fire as you think, walk, run, sit, and eat adenosine levels in the body start to increase. This increase is detected by adenosine receptors, which send signals to the brain telling you that it’s time for a nap.
As shown in the picture above, adenosine and caffeine have a vaguely similar molecular structure. This similarity is critical in what makes caffeine work. Because of it, caffeine is able to bind to adenosine receptors and block them. This prevents the receptors from being able to monitor adenosine levels and relay the information to the brain. Essentially, caffeine stops adenosine receptors from telling the brain that you’re tired.
But caffeine doesn’t just stop you from feeling sleepy; it gives you that pleasant buzz as well. How does this factor into the caffeine molecule’s effect? Basically, the blockage of adenosine receptors in the brain allows the dopamine centre of the brain to run rampant and start pumping out the feel-good chemical like crazy. To add to the buzz, high adenosine levels in the blood trigger the release of adrenaline, which is why some people swear by caffeine when it comes to productivity.
Does Caffeine Have Side Effects?
In the short term, consuming too much caffeine at a time blocks up too many of the brain’s adenosine receptors. Adenosine levels in the body get higher and higher and the chemical has nowhere to go. Eventually, once the caffeine wears off and the poor receptors are able to function normally again they’re hit with a huge rush of adenosine and start sending frantic demands to the brain for sleep. This is what causes the 'crash' that many people experience after drinking too much caffeine. This fatigue is generally accompanied by other symptoms, such as dizziness, a dry mouth, tremors, blurred vision and irritability.
Long-term reliance on large amounts of caffeine can have some pretty scary side effects. These include osteoporosis, high blood pressure, heart disease, heartburn, ulcers, infertility, and mental health issues like anxiety and depression. While it seems harmless when friends and coworkers rave about how they can’t function without coffee, caffeine dependency is serious stuff and shouldn’t be taken lightly. If you’re about to have your fourth cup of coffee of the day, maybe consider putting it down and drinking some water instead.
Caffeine, or 1,3,7-trimethylxanthine, is a nitrogenous molecule that comes from a variety of natural sources like tea leaves, coffee beans and cacao. Because of its similarity to the neurochemical adenosine caffeine is able to block adenosine receptors, which surpasses the "time to sleep" messages that the receptors send to the brain. This causes the consumer to feel more alert. The other effects of caffeine come from the increased dopamine and adrenaline secretion caused as a side effect of the blockage of adenosine receptors. While caffeine isn’t particularly dangerous as far as drugs can go, consuming too much of it can cause a caffeine 'crash,' and in the long term can lead to more serious side effects like heart disease, infertility and addiction.
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© 2018 K S Lane